Parkinson's disease/Parkinson syndromes—mitochondrial abnormalities

• Publisher: John Wiley and Sons
• Year: 1992
• Tongue: English
• Weight: 237 KB
• Volume: 7
• Category: Article
• ISSN: 0885-3185
• DOI: 10.1002/mds.870070535

✦ Synopsis

Recently, it was reported that parkinsonlan patients exhibit mitochondrial abnormalhies which might be related to the production of either endogenous or exogenous toxins. We, thus, assessed possible inhibitory effects of dopamine-related compounds on mitochondrial respiration in rat brain. We found that L-DOPA, dopamine, norepinephrine, 6-hydroxydopa. 6hydroxydopamine and fluphenazine caused significant inhibition of Complexes I and 111 activities. In contrast, no significant inhibition was observed on complexes i I and iV activities except for the higher doses of 6hydroxydopamine and fluphenazlne. Because these compounds generate oxygen-based radicals during their metabolism, it is possible that a free radicalmediated toxic process is invovied in these changes.