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Parkinson's disease/Parkinson syndromes—apomorphine

Publisher
John Wiley and Sons
Year
1992
Tongue
English
Weight
381 KB
Volume
7
Category
Article
ISSN
0885-3185

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✦ Synopsis

We report clinical data on six Parkinsonian patients on long term L-dopa therapy who complained of short, but clear deterioration of parkinsonian symptoms imediatly after L-dopa intake.

After an oral challenge with 275mg L-dopdcarbidopa (and apomorphine 3mg SC in two cases) patients were assessed every 10 minutes with webster scale, and timed tapping and walking test.

In all the patients tested with an acute L-dopa challenge a deterioration below the basal line in parkinsonian symptoms was observed after 10-20 minutes. The latency and duration of beginning of dose motor deterioration was shorter after the apomorphine test, but the characteristics were similar. of L-dopa acting via pre-synaptic dopamine receptors.

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