Parallel solid-phase synthesis of mucin-like glycopeptides
β Scribed by Mian Liu; George Barany; David Live
- Book ID
- 108080262
- Publisher
- Elsevier Science
- Year
- 2005
- Tongue
- English
- Weight
- 247 KB
- Volume
- 340
- Category
- Article
- ISSN
- 0008-6215
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π SIMILAR VOLUMES
Short glycopeptides derived from salivary mucin have been synthesized in order to delineate the O-glycosylation pattern that is important in the biological activity of mucin. Two glycopeptides, APPETT\*AAP-OMe and PAPPSS\*SAP-OMe (\* = e~-D-GalNAc), were prepared by solid-phase peptide synthesis int
The simultaneous synthesis of 40 different s-linked O-glycopeptides from human intestinal mucin and porcine submaxillary gland mucin in a manual multiple column peptide synthesizer using the new glycosylamino acid building blocks Na-Fmoc-Ser(Ac3-~-D-GalpNAc)-OPfp (3) and Na-Fmoc-Thr(Ac3-~-D-GalpNAc)