A versatile method for the solid phase synthesis of oxazolidin-2-ones is described. A resin bound phenolic group was treated with (ยฑ)-epichlorohydrin followed by opening of the epoxide ring with sodium azide. The resulting 1-azido-3-aryloxypropan-2-ol was treated with p-nitrophenylchloroformate and
Parallel Solid-Phase Synthesis of Disubstituted 1,6-Piperazine-2-ones
โ Scribed by Nefzi, Adel; Mimna, Richard A.; Houghten, Richard A.
- Book ID
- 127383687
- Publisher
- American Chemical Society
- Year
- 2002
- Tongue
- English
- Weight
- 69 KB
- Volume
- 4
- Category
- Article
- ISSN
- 1520-4766
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The solid supported synthesis of functionalized 1,2,4-triazin-6-ones from resin bound amino acids and acid chlorides is described. A thioamide intermediate is generated with Lawesson's reagent, and the final products are cyclized and cleaved from resin with hydrazine. The products are obtained in go
We have developed a solid-phase synthesis of diverse 1,3-disubstituted 2-thioxoquinazoline-4-ones. In this synthesis, the fluorine atom on support-bound 2-fluoro-5-nitrobenzoyl amides was substituted with various primary amines, followed by cyclization with thiocarbonyldiimidazole. Since 1-substitut