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Pancreatic Lesions in von Hippel-Lindau Syndrome: The Coexistence of Metastatic Tumors from Renal Cell Carcinoma and Multiple Cysts

✍ Scribed by Masafumi Kogire; Ryo Hosotani; Masato Kondo; Kyo Itoh; Ryuichiro Doi; Toshiro Terachi; Masayuki Imamura


Book ID
113050145
Publisher
Springer
Year
2000
Tongue
English
Weight
603 KB
Volume
30
Category
Article
ISSN
1436-2813

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Germline mutations in the von Hippel-Lindau (VHL) disease tumor suppressor gene (TSG) convey a high risk of clear-cell renal-cell carcinoma (CC-RCC) and most sporadic CC-RCCs demonstrate somatic inactivation of the VHL TSG. However, the existence of further CC-RCC gatekeeper genes is implied by CC-R