Inactivation of tumour suppressor gene(s) (TSGs) on 3p appears to be a critical event in the pathogenesis of clear cell renal cell carcinoma (CC-RCC). Analysis of loss of heterozygosity (LOH) in sporadic RCC samples has implicated roles for TSGs in three specific regions of 3p in RCC development: (1
✦ LIBER ✦
Novel mutations of the von Hippel-Lindau tumor-suppressor gene and rare DNA hypermethylation in renal-cell carcinoma cell lines of the clear-cell type
✍ Scribed by Alexander J. Meyer; Ana Hernandez; Andrea R. Florl; Jürgen Enczmann; Claus-Dieter Gerharz; Wolfgang A. Schulz; Peter Wernet; Rolf Ackermann
- Publisher
- John Wiley and Sons
- Year
- 2000
- Tongue
- French
- Weight
- 120 KB
- Volume
- 87
- Category
- Article
- ISSN
- 0020-7136
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Germline mutations in the von Hippel-Lindau (VHL) disease tumor suppressor gene (TSG) convey a high risk of clear-cell renal-cell carcinoma (CC-RCC) and most sporadic CC-RCCs demonstrate somatic inactivation of the VHL TSG. However, the existence of further CC-RCC gatekeeper genes is implied by CC-R