Cloning of the Rat Homologue of the von Hippel-Lindau Tumor Suppressor Gene and Its Non-somatic Mutation in Rat Renal Cell Carcinomas
โ Scribed by Kikuchi, Yasushi ;Kobayashi, Etsuko ;Nishizawa, Masae ;Hamazaki, Shuji ;Okada, Shigeru ;Hino, Okio
- Book ID
- 108581033
- Publisher
- Wiley (Blackwell Publishing)
- Year
- 1995
- Tongue
- English
- Weight
- 283 KB
- Volume
- 86
- Category
- Article
- ISSN
- 0910-5050
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## Abstract It has been documented that renal cell carcinomas (RCCs) occur frequently in patients treated with longโterm dialysis, especially in cases of endโstage renal disease (ESRD)/acquired cystic disease of the kidney (ACDK). To address the molecular pathogenesis of ESRD/ACDKโassociated RCCs,
Germline mutations in the von Hippel-Lindau (VHL) disease tumor suppressor gene (TSG) convey a high risk of clear-cell renal-cell carcinoma (CC-RCC) and most sporadic CC-RCCs demonstrate somatic inactivation of the VHL TSG. However, the existence of further CC-RCC gatekeeper genes is implied by CC-R