## Abstract It has been documented that renal cell carcinomas (RCCs) occur frequently in patients treated with long‐term dialysis, especially in cases of end‐stage renal disease (ESRD)/acquired cystic disease of the kidney (ACDK). To address the molecular pathogenesis of ESRD/ACDK‐associated RCCs,
✦ LIBER ✦
Renal cell carcinomas in trichloroethene(TRI) exposed persons are associated with somatic mutations in the von Hippel-Lindau (VHL) tumour suppressor gene
✍ Scribed by Thomas Brüning; Gregor Weirich; M. A. Hornauer; Heinz Höfler; Hiltrud Brauch
- Book ID
- 105871469
- Publisher
- Springer-Verlag
- Year
- 1997
- Tongue
- English
- Weight
- 131 KB
- Volume
- 71
- Category
- Article
- ISSN
- 0340-5761
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Inactivation of tumour suppressor gene(s) (TSGs) on 3p appears to be a critical event in the pathogenesis of clear cell renal cell carcinoma (CC-RCC). Analysis of loss of heterozygosity (LOH) in sporadic RCC samples has implicated roles for TSGs in three specific regions of 3p in RCC development: (1