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Expression of HIF-1 and ubiquitin in conventional renal cell carcinoma: relationship to mutations of the von Hippel–Lindau tumor suppressor gene

✍ Scribed by Michael D. Hughson; Zhi He; Shawn Liu; John Coleman; W.Bruce Shingleton


Book ID
114135555
Publisher
Elsevier Science
Year
2003
Tongue
English
Weight
410 KB
Volume
143
Category
Article
ISSN
0165-4608

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## Abstract Hypoxia–inducible factor (HIF) remains the central focus of oxygen sensing during hypoxia. HIF is a heterodimeric transcription factor consisting of an oxygen‐regulated alpha‐ and a constitutively expressed beta subunit. The von Hippel‐Lindau tumor suppressor (pVHL) is a component of th