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Overproduction of Vascular Endothelial Growth Factor Related to von Hippel-Lindau Tumor Suppressor Gene Mutations and Hypoxia-Inducible Factor-1α Expression in Renal Cell Carcinomas.

✍ Scribed by NA, X.I.; WU, GUAN; RYAN, CHARLOTTE K.; SCHOEN, SUSAN R.; di’SANTAGNESE, P. ANTHONY; MESSING, EDWARD M.


Book ID
122086112
Publisher
Lippincott Williams and Wilkins
Year
2003
Tongue
English
Weight
575 KB
Volume
170
Category
Article
ISSN
0022-5347

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## Abstract ## BACKGROUND A high frequency of genetic alterations of the von Hippel‐Lindau (__VHL)__ gene and overexpression of the vascular endothelial growth factor (__VEGF)__ gene have been observed independently in human sporadic renal cell carcinoma (RCCs), but to the authors' knowledge the a