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Von Hippel-Lindau Tumor Suppressor Gene Loss in Renal Cell Carcinoma Promotes Oncogenic Epidermal Growth Factor Receptor Signaling via Akt-1 and MEK-1

✍ Scribed by S. Justin Lee; Jean-Baptiste Lattouf; Julie Xanthopoulos; W. Marston Linehan; Donald P. Bottaro; James R. Vasselli


Book ID
111864860
Publisher
Elsevier Science
Year
2008
Tongue
English
Weight
1023 KB
Volume
54
Category
Article
ISSN
0302-2838

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Germline mutations in the von Hippel-Lindau (VHL) disease tumor suppressor gene (TSG) convey a high risk of clear-cell renal-cell carcinoma (CC-RCC) and most sporadic CC-RCCs demonstrate somatic inactivation of the VHL TSG. However, the existence of further CC-RCC gatekeeper genes is implied by CC-R