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Palladium-Catalyzed Synthesis of Cephalotaxine Analogues

✍ Scribed by Lutz F. Tietze; Hartmut Schirok; Michael Wöhrmann

Publisher
John Wiley and Sons
Year
2000
Tongue
English
Weight
193 KB
Volume
6
Category
Article
ISSN
0947-6539

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Highly Efficient Synthesis of Cephalotaxin by Two Palladium-Catalyzed Cyclizations. -The racemic intermediate (V) is converted with 75% yield by known procedures in 4 steps into the alkaloid cephalotaxin (VI), the parent compound of the antileukemic harringtonines. -(TIETZE,