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ChemInform Abstract: Highly Efficient Synthesis of Cephalotaxin by Two Palladium-Catalyzed Cyclizations.

✍ Scribed by L. F. TIETZE; H. SCHIROK

Publisher
John Wiley and Sons
Year
2010
Weight
30 KB
Volume
28
Category
Article
ISSN
0931-7597

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✦ Synopsis

Highly Efficient Synthesis of Cephalotaxin by Two Palladium-Catalyzed Cyclizations.

-The racemic intermediate (V) is converted with 75% yield by known procedures in 4 steps into the alkaloid cephalotaxin (VI), the parent compound of the antileukemic harringtonines. -(TIETZE,

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D-homo-Cephalotaxine analogues 19 and 23 have been prepared by intramolecular Heck reactions of 12 and 22. The substrates 12 and 22 were obtained by alkylation and acyl- [a]