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Highly Efficient Synthesis of Cephalotaxine by Two Palladium-Catalyzed Cyclizations

✍ Scribed by Prof. Dr. Lutz F. Tietze; Dipl.-Chem. Hartmut Schirok


Publisher
John Wiley and Sons
Year
1997
Tongue
English
Weight
227 KB
Volume
36
Category
Article
ISSN
0044-8249

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πŸ“œ SIMILAR VOLUMES


ChemInform Abstract: Highly Efficient Sy
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Highly Efficient Synthesis of Cephalotaxin by Two Palladium-Catalyzed Cyclizations. -The racemic intermediate (V) is converted with 75% yield by known procedures in 4 steps into the alkaloid cephalotaxin (VI), the parent compound of the antileukemic harringtonines. -(TIETZE,

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D-homo-Cephalotaxine analogues 19 and 23 have been prepared by intramolecular Heck reactions of 12 and 22. The substrates 12 and 22 were obtained by alkylation and acyl- [a]