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P4E108 - Effect of chloroform, haloacetic acids and trichloroethylene on DNA methylation in liver and tumors of female B6C3F1 mice

✍ Scribed by M.A. Pereira; P.M. Kramer; R. Ge; L. Tao

Book ID
119540647
Publisher
Elsevier Science
Year
1998
Tongue
English
Weight
138 KB
Volume
95
Category
Article
ISSN
0378-4274

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## Abstract The chlorine disinfection by‐products, dichloroacetic acid (DCA) and trichloroacetic acid (TCA), are carcinogenic in mouse liver. We have previously reported that DCA and TCA induced DNA hypomethylation in mouse liver. In the present study, we determined the temporal association for DNA