p21 WAF1/Cip1 is an inhibitor of cdk/cyclin complexes, and thus regulates the cell cycle. p21 is also related to cell differentiation and is regulated by wild-type p53, although p53-independent regulatory pathways have been proposed. In order to analyse p21 expression as well as its relationship wit
P21Cip1/WAF1 expression is strongly associated with HPV-positive tonsillar carcinoma and a favorable prognosis
✍ Scribed by Hafkamp, Harriët C; Mooren, Jeroen J; Claessen, Sandra MH; Klingenberg, Boris; Voogd, Adri C; Bot, Fredrik J; Klussmann, J Peter; Hopman, Anton HN; Manni, Johannes J; Kremer, Bernd
- Book ID
- 109887775
- Publisher
- Nature Publishing Group
- Year
- 2009
- Tongue
- English
- Weight
- 464 KB
- Volume
- 22
- Category
- Article
- ISSN
- 0893-3952
No coin nor oath required. For personal study only.
📜 SIMILAR VOLUMES
p21 WAF1/Cip1 is a recently identified gene involved in cell cycle regulation through cyclin-CDK-complex inhibition. The expression of this gene in several cell lines seems to be induced by wild-type, but not mutant, p53. p21 WAF1/Cip1 expression has been studied at both mRNA and protein levels in a
## RESULTS. Various levels of p21 and p53 immunoreactivities in carcinoma cells were detected in 30 (32%) and 60 (65%), respectively, of 93 samples. There was no 1 First Department of Pathology, Faculty of Medcorrelation between p21 and p53 expression. The 5-year survival rate of patients icine, T
## Abstract We have used HeLa cells without mitochondrial DNA (ρ^0^‐cells) and transient ρ^0^‐phenocopies, obtained from wild‐type cells by short‐term treatment with ethidium bromide, to analyze how the absence of a functional mitochondrial respiratory chain slows down proliferation. We ruled out a