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p21/WAF1 expression in human colorectal carcinoma: association with p53, transcription factor AP-2 and prognosis

✍ Scribed by Kosma, V-M; Ropponen, K M; Kellokoski, J K; Lipponen, P K; Pietiläinen, T; Eskelinen, M J; Alhava, E M

Book ID
110002449
Publisher
Nature Publishing Group
Year
1999
Tongue
English
Weight
316 KB
Volume
81
Category
Article
ISSN
0007-0920

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p21WAF1/CIP1 expression in colorectal ca
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✍ Viale, Giuseppe; Pellegrini, Caterina; Mazzarol, Giovanni; Maisonneuve, Patrick; 📂 Article 📅 1999 🏛 John Wiley and Sons 🌐 English ⚖ 221 KB 👁 3 views

Defects in the mechanisms controlling the cell cycle are crucial in cell transformation and/or tumour progression. p21 WAF1/CIP1 is an inhibitor of cyclin-dependent kinases, induced by p53-dependent and p53-independent pathways, which can block progression through the cell cycle. p21 WAF1/CIP1 expre