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p16INK4andp15INK4BAlterations in Primary Gynecologic Malignancy

✍ Scribed by Y.F. Wong; T.K.H. Chung; T.H. Cheung; T. Nobori; S.F. Yim; K.W.H. Lai; A.L. Yu; M.B. Diccianni; T.Z. Li; A.M.Z. Chang

Book ID
115617175
Publisher
Elsevier Science
Year
1997
Tongue
English
Weight
142 KB
Volume
65
Category
Article
ISSN
0090-8258

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The p p ! 6INK4 and p I8 genes are members of the gene famil coding for inhibitors of cyclin-dependent kinases 4 and 6. frequently deleted in many human neoplasms. To examine the role of these 3 genes in lung carcinogenesis, somatic mutations within the genes were analyzed by single-strand conformat