P163 Sequential and comparative Zap-70 and CD38 analysis in chronic lymphoid leukemia patients

✍ Scribed by Zs. Hevessy; E. Karaszi; A. Frendl; F. Kiss; G. Pfliegler; J. Kappelmayer

• Publisher: Elsevier Science
• Year: 2007
• Tongue: English
• Weight: 59 KB
• Volume: 21
• Category: Article
• ISSN: 0268-960X
• DOI: 10.1016/s0268-960x(07)70242-4

✦ Synopsis

lymphocytic leukemia. Besides establishing the demographic characteristics of 322 CLL cases studied, CD38 and ZAP7o was investigated in 58 vs. 64% of the cases while in 57% of the CLL cases FISH analysis for +12,13q ,11q and 17p was possible. Results: (1) The frequency of FISH detected aberrations in 183 CLL patients showed up 20.6; 59.5;11.4 and 8.4% for +12, 13q , 11q and 17p respectively which seems to be in good concordance with literature data. (2) The occurence of ZAP 70 level >20% was more frequent in those CLL cases requiring early therapeutic interventions (1 2 years after the diagnosis).

(3) None of the FISH markers were associated with the time elapsing between the diagnosis and the start of the therapy for CLL. (4) CLL cases with long survival (> 10 years from diagnosis) have revealed an underrepresentation of 11q .

Conclusion:

Prospective studies will answer to what extent these biological parameters will have a role in the risk adopted therapy for CLL.

P160 Alemtuzumab-induced apoptosis in vitro in chronic lymphocytic leukemia with p53 deletion