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A robust ratio metric method for analysis of Zap-70 expression in chronic lymphocytic leukemia (CLL)

✍ Scribed by Antony C. Bakke; Zoe Purtzer; Jose Leis; James Huang


Publisher
John Wiley and Sons
Year
2006
Tongue
English
Weight
416 KB
Volume
70B
Category
Article
ISSN
1552-4949

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## Abstract ## Background: Zeta‐chain associated protein of 70kDa (ZAP‐70) is the most promising surrogate marker for the immunoglobulin heavy chain variable region (IgV~H~) mutation status in B‐cell chronic lymphocytic leukemia (B‐CLL). Crespo et al. proposed the detection of ZAP‐70 by flow cytom

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## Abstract Among 14 peripheral blood samples obtained from patients affected by B chronic lymphocytic leukemia (B‐CLL) at initial stages (Rai 0–1) of the disease, 6 showed intermediate/high levels of Zap‐70 while 8 displayed low/absent levels of Zap‐70. Although Zap‐70^high^ and Zap‐70^low^ B‐CLL