Comparative analysis of ZAP-70 expression and Ig VH mutational status in B-cell chronic lymphocytic leukemia
✍ Scribed by Luz Muñoz; Adriana Lasa; Maria T. Carricondo; Carmen Hernández; Josep Ubeda; Josep F. Nomdedéu
- Publisher
- John Wiley and Sons
- Year
- 2007
- Tongue
- English
- Weight
- 734 KB
- Volume
- 72B
- Category
- Article
- ISSN
- 1552-4949
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## Abstract ## Background: Zeta‐chain associated protein of 70kDa (ZAP‐70) is the most promising surrogate marker for the immunoglobulin heavy chain variable region (IgV~H~) mutation status in B‐cell chronic lymphocytic leukemia (B‐CLL). Crespo et al. proposed the detection of ZAP‐70 by flow cytom
## Abstract ## Background: Expression of T cell specific zeta‐associated protein 70 (ZAP‐70) by B‐cell chronic lymphocytic leukemia (B‐CLL) cells, as investigated by flow cytometry, has both prognostic relevance and predictive power as surrogate for immunoglobulin heavy chain variable region (IgV~
## Abstract Among 14 peripheral blood samples obtained from patients affected by B chronic lymphocytic leukemia (B‐CLL) at initial stages (Rai 0–1) of the disease, 6 showed intermediate/high levels of Zap‐70 while 8 displayed low/absent levels of Zap‐70. Although Zap‐70^high^ and Zap‐70^low^ B‐CLL