An improved flow cytometric method using FACS Lysing Solution for measurement of ZAP-70 expression in B-cell chronic lymphocytic leukemia

Comparison of methods for determining ze

Comparison of methods for determining zeta-chain associated protein – 70 (ZAP-70) expression in patients with B-cell chronic lymphocytic leukemia (B-CLL)

✍ Agnieszka Bojarska-Junak; Krzysztof Giannopoulos; Malgorzata Kowal; Anna Dmoszyń 📂 Article 📅 2006 🏛 John Wiley and Sons 🌐 English ⚖ 471 KB 👁 1 views

## Abstract ## Background: Zeta‐chain associated protein of 70kDa (ZAP‐70) is the most promising surrogate marker for the immunoglobulin heavy chain variable region (IgV~H~) mutation status in B‐cell chronic lymphocytic leukemia (B‐CLL). Crespo et al. proposed the detection of ZAP‐70 by flow cytom