Dose-dependent pharmacokinetics of toxic
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Byung Hwa Jung; Bo Jun Kim; Min Sun Lee; Joo Hyun Lee; Ju-Hee Oh; Young-Joo Lee
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Article
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2010
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John Wiley and Sons
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English
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## Abstract It has been reported that urinary excretion of two metabolites of valproic acid (VPA), 4โeneโvalproic acid (4โVPA) and 2,4โdieneโvalproic acid (2,4โVPA), increased exponentially with the administration of high doses of VPA, and this increased formation of toxic metabolites could be rela