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P162 clinical pharmacokinetics of etoposide during high-dose treatment in relation to toxicity

โœ Scribed by Stremetzne, S.; Jaehde, U.; Beyer, J.; Steuer, J.; Siegert, W.; Schunack, W.


Book ID
122352842
Publisher
Elsevier Science
Year
1994
Tongue
English
Weight
135 KB
Volume
2
Category
Article
ISSN
0928-0987

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## Abstract It has been reported that urinary excretion of two metabolites of valproic acid (VPA), 4โ€eneโ€valproic acid (4โ€VPA) and 2,4โ€dieneโ€valproic acid (2,4โ€VPA), increased exponentially with the administration of high doses of VPA, and this increased formation of toxic metabolites could be rela