Pharmacokinetics of high-dose busulphan in relation to age and chronopharmacology
✍ Scribed by M. Hassan; G. Öberg; A. N. Bekassy; J. Aschan; H. Ehrsson; P. Ljungman; G. Lönnerholm; B. Smedmyr; A. Taube; I. Wallin; B. Simonsson
- Publisher
- Springer
- Year
- 1991
- Tongue
- English
- Weight
- 532 KB
- Volume
- 28
- Category
- Article
- ISSN
- 0344-5704
No coin nor oath required. For personal study only.
📜 SIMILAR VOLUMES
## Abstract The effects of age and dose on the pharmacokinetics of ketoprofen were evaluated in young adult and senescent male Fischer 344 rats following intravenous administration of 2·5 and 10 mg kg^−1^. Plasma concentrations were measured by HPLC and free ketoprofen determined by equilibrium dia
## Abstract It has been reported that urinary excretion of two metabolites of valproic acid (VPA), 4‐ene‐valproic acid (4‐VPA) and 2,4‐diene‐valproic acid (2,4‐VPA), increased exponentially with the administration of high doses of VPA, and this increased formation of toxic metabolites could be rela