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Oxidized proteins: Intracellular distribution and recognition by the proteasome

✍ Scribed by Tobias Jung; Nicolle Bader; Tilman Grune


Book ID
116177838
Publisher
Elsevier Science
Year
2007
Tongue
English
Weight
457 KB
Volume
462
Category
Article
ISSN
0003-9861

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## Abstract The generation of free radicals and the resulting oxidative modification of cell structures are omnipresent in mammalian cells. This includes the permanent oxidation of proteins leading to the disruption of the protein structure and an impaired functionality. In consequence, these oxidi