## Abstract The degradation of the majority of cellular proteins is mediated by the proteasomes. Ubiquitinβdependent proteasomal protein degradation is executed by a number of enzymes that interact to modify the substrates prior to their engagement with the 26S proteasomes. Alternatively, certain p
β¦ LIBER β¦
Degradation of oxidized proteins by the 20S proteasome
β Scribed by Kelvin J.A. Davies
- Book ID
- 117456593
- Publisher
- Elsevier Science
- Year
- 2001
- Tongue
- English
- Weight
- 276 KB
- Volume
- 83
- Category
- Article
- ISSN
- 0300-9084
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## Abstract The generation of free radicals and the resulting oxidative modification of cell structures are omnipresent in mammalian cells. This includes the permanent oxidation of proteins leading to the disruption of the protein structure and an impaired functionality. In consequence, these oxidi