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Oxidative DNA damage in mild cognitive impairment and late-stage Alzheimer's disease

✍ Scribed by Lovell, M. A.; Markesbery, W. R.

Book ID
118046830
Publisher
Oxford University Press
Year
2007
Tongue
English
Weight
582 KB
Volume
35
Category
Article
ISSN
0305-1048

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## Abstract Increasing evidence supports a role for oxidative damage in the pathogenesis of Alzheimer's disease (AD). Multiple studies show significantly increased levels of lipid peroxidation and protein, DNA, and RNA oxidation in vulnerable regions of the brain of patients with late‐stage AD (LAD