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Oxidative damage and mitochondrial dysfunction in patients with mild cognitive impairment and Alzheimer's disease

✍ Scribed by Baldeiras, Inês; Santana, Isabel; Proença, Maria Teresa; Garrucho, Maria Helena; Pascoal, Rui; Rodrigues, Ana; Duro, Diana; Silva, Diana F.F.; Cardoso, Sandra M.; Oliveira, Catarina

Book ID
123179288
Publisher
Elsevier Science
Year
2010
Tongue
English
Weight
252 KB
Volume
6
Category
Article
ISSN
1552-5260

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✍ Mark A. Lovell; William R. Markesbery 📂 Article 📅 2007 🏛 John Wiley and Sons 🌐 English ⚖ 93 KB 👁 1 views

## Abstract Increasing evidence supports a role for oxidative damage in the pathogenesis of Alzheimer's disease (AD). Multiple studies show significantly increased levels of lipid peroxidation and protein, DNA, and RNA oxidation in vulnerable regions of the brain of patients with late‐stage AD (LAD