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Overexpression of RFT induces G1–S arrest and apoptosis via p53/p21Waf1 pathway in glioma cell

✍ Scribed by Hideyuki Kano; Yoshiki Arakawa; Jun A Takahashi; Kazuhiko Nozaki; Yasuhiro Kawabata; Kenji Takatsuka; Ryoichiro Kageyama; Tetsuya Ueba; Nobuo Hashimoto

Book ID: 116288229
Publisher: Elsevier Science
Year: 2004
Tongue: English
Weight: 444 KB
Volume: 317
Category: Article
ISSN: 0006-291X
DOI: 10.1016/j.bbrc.2004.03.120

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## Transforming growth factor-␤1 (TGF-␤) inhibits cell-cycle progression of many types of cells by arresting them in G 1 /S phase through inhibition of the active cyclin-Cdk complexes that lead to inhibition of Rb phosphorylation. In gastriccancer cells, SNU16, TGF-␤ treatment induced enhanced exp