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Overexpression of insulin-like growth factor binding protein-1 in transgenic mice

✍ Scribed by Murphy, L. J.

Book ID: 113045703
Publisher: Springer
Year: 2000
Tongue: English
Weight: 41 KB
Volume: 14
Category: Article
ISSN: 0931-041X
DOI: 10.1007/s004670000347

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## Abstract Insulin‐like growth factor binding protein‐1 (IGFBP‐1) is synthesized in the liver and regulates the mitogenic effects of the insulin‐like growth factors (IGFs). The evidence that IGFBP‐1 plays a role in hepatocarcinogenesis, however, is equivocal. We have, therefore, investigated the d