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Insulin-like growth factor-I overexpression in the testes of transgenic mice

✍ Scribed by M.K Dyck; M Ouellet; M Gagné; F Pothier

Book ID
117272079
Publisher
Elsevier Science
Year
1999
Tongue
English
Weight
61 KB
Volume
51
Category
Article
ISSN
0093-691X

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Using insulin-like growth factor-I (IGF-I)-overexpressing transgenic (Tg) mice as a model, we have shown that IGF-I promotes myelination by increasing the number of oligodendrocytes and stimulating the expression of myelin-specific protein genes. In the present study, we investigated whether IGF-I p