Osteoblast-specific expression of insulin-like growth factor-1 in bone of transgenic mice induces insulin-like growth factor binding protein-5
β Scribed by Meilan M. Rutter; Edith Markoff; Lisa Clayton; Nagako Akeno; Guisheng Zhao; Thomas L. Clemens; Steven D. Chernausek
- Book ID
- 116319076
- Publisher
- Elsevier Science
- Year
- 2005
- Tongue
- English
- Weight
- 268 KB
- Volume
- 36
- Category
- Article
- ISSN
- 8756-3282
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## Abstract Insulinβlike growth factor binding proteinβ1 (IGFBPβ1) is synthesized in the liver and regulates the mitogenic effects of the insulinβlike growth factors (IGFs). The evidence that IGFBPβ1 plays a role in hepatocarcinogenesis, however, is equivocal. We have, therefore, investigated the d