Overexpression of indoleamine 2,3-dioxygenase in human inflammatory bowel disease
β Scribed by Anna Maria Wolf; Dominik Wolf; Holger Rumpold; Alexander R. Moschen; Arthur Kaser; Peter Obrist; Dietmar Fuchs; Gerald Brandacher; Christiane Winkler; Karel Geboes; Paul Rutgeerts; Herbert Tilg
- Book ID
- 116366203
- Publisher
- Elsevier Science
- Year
- 2004
- Tongue
- English
- Weight
- 906 KB
- Volume
- 113
- Category
- Article
- ISSN
- 1090-2341
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## Abstract Human indoleamine 2,3βdioxygenase (hIDO), a monomeric heme enzyme, catalyzes the oxidative degradation of Lβtryptophan (LβTrp) and other indoleamine derivatives. Its activity follows typical MichaelisβMenten behavior only for LβTrp concentrations up to 50 ΞΌM; a further increase in the c
## Abstract The activity of indoleamine 2, 3-dioxygenase (IDO; E.C. 1.13.11.42) catalyzes the oxidative cleavage of tryptophan to form kynurenine. IDO activity consumes superoxide anions; therefore, we postulated that over-expression of IDO might mitigate superoxide-anion dependent, oxidative modif