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Intact indoleamine 2,3-dioxygenase activity in human chronic granulomatous disease

✍ Scribed by Birgit Jürgens; Dietmar Fuchs; Janine Reichenbach; Andreas Heitger

Book ID
113541854
Publisher
Elsevier Science
Year
2010
Tongue
English
Weight
274 KB
Volume
137
Category
Article
ISSN
1090-2341

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## Abstract Human indoleamine 2,3‐dioxygenase (hIDO), a monomeric heme enzyme, catalyzes the oxidative degradation of L‐tryptophan (L‐Trp) and other indoleamine derivatives. Its activity follows typical Michaelis–Menten behavior only for L‐Trp concentrations up to 50 μM; a further increase in the c