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Induction of indoleamine 2,3-dioxygenase activity in human native astrocytes

✍ Scribed by W. Däubener; C. MacKenrie; U. Hadding; F. Aloisi


Book ID
116103162
Publisher
Elsevier Science
Year
1995
Tongue
English
Weight
192 KB
Volume
63
Category
Article
ISSN
0165-5728

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## Abstract Human indoleamine 2,3‐dioxygenase (hIDO), a monomeric heme enzyme, catalyzes the oxidative degradation of L‐tryptophan (L‐Trp) and other indoleamine derivatives. Its activity follows typical Michaelis–Menten behavior only for L‐Trp concentrations up to 50 μM; a further increase in the c