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Gene structure of human indoleamine 2,3-dioxygenase

✍ Scribed by Akihiko Kadoya; Shigenobu Tone; Hiroyasu Maeda; Yohsuke Minatogawa; Ryo Kido


Book ID
115765416
Publisher
Elsevier Science
Year
1992
Tongue
English
Weight
743 KB
Volume
189
Category
Article
ISSN
0006-291X

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## Abstract Human indoleamine 2,3‐dioxygenase (hIDO), a monomeric heme enzyme, catalyzes the oxidative degradation of L‐tryptophan (L‐Trp) and other indoleamine derivatives. Its activity follows typical Michaelis–Menten behavior only for L‐Trp concentrations up to 50 ΞΌM; a further increase in the c