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Expression and Purification of Recombinant Human Indoleamine 2,3-Dioxygenase

โœ Scribed by Tamantha K. Littlejohn; Osamu Takikawa; Daniel Skylas; Joanne F. Jamie; Mark J. Walker; Roger J.W. Truscott


Book ID
115645632
Publisher
Elsevier Science
Year
2000
Tongue
English
Weight
99 KB
Volume
19
Category
Article
ISSN
1046-5928

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## Abstract Human indoleamine 2,3โ€dioxygenase (hIDO), a monomeric heme enzyme, catalyzes the oxidative degradation of Lโ€tryptophan (Lโ€Trp) and other indoleamine derivatives. Its activity follows typical Michaelisโ€“Menten behavior only for Lโ€Trp concentrations up to 50 ฮผM; a further increase in the c