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Indoleamine 2,3-Dioxygenase Expression in Human Cancers: Clinical and Immunologic Perspectives

✍ Scribed by Godin-Ethier, Jessica (author);Hanafi, Laïla Aïcha (author);Piccirillo, Ciriaco A. (author);Lapointe, Réjean (author)

Book ID
115523685
Publisher
American Association for Cancer Research
Year
2011
Tongue
English
Weight
471 KB
Volume
17
Category
Article
ISSN
1078-0432

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## Abstract Human indoleamine 2,3‐dioxygenase (hIDO), a monomeric heme enzyme, catalyzes the oxidative degradation of L‐tryptophan (L‐Trp) and other indoleamine derivatives. Its activity follows typical Michaelis–Menten behavior only for L‐Trp concentrations up to 50 μM; a further increase in the c