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Oropharyngeal Skeletal Disease Accompanying High Bone Mass and Novel LRP5 Mutation

✍ Scribed by Michael R Rickels; Xiafang Zhang; Steven Mumm; Michael P Whyte


Book ID
111485223
Publisher
American Society for Bone and Mineral Research
Year
2004
Tongue
English
Weight
712 KB
Volume
20
Category
Article
ISSN
0884-0431

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## Abstract The __Lrp5__ gene is a major determinant of bone mass accrual. It has been demonstrated recently to achieve this function by hampering the synthesis of gut‐derived serotonin, which is a powerful inhibitor of bone formation. In this study we analyzed plasma serotonin levels in patients w

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## Abstract Patients with an activation mutation of the __Lrp5__ gene exhibit high bone mass (HBM). Limited information is available regarding compartment‐specific changes in bone. The relationship between the phenotype and serum serotonin is not well documented. To evaluate bone, serotonin, and bo