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Patients with high-bone-mass phenotype owing to Lrp5-T253I mutation have low plasma levels of serotonin

✍ Scribed by Morten Frost; Tom Erenskjold Andersen; Vijay Yadav; Kim Brixen; Gerard Karsenty; Moustapha Kassem

Book ID
102300280
Publisher
American Society for Bone and Mineral Research
Year
2010
Tongue
English
Weight
32 KB
Volume
25
Category
Article
ISSN
0884-0431

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Patients with high-bone-mass phenotype o
Patients with high-bone-mass phenotype owing to Lrp5-T253I mutation have low plasma levels of serotonin
✍ Morten Frost; Tom Erenskjold Andersen; Vijay Yadav; Kim Brixen; Gerard Karsenty; πŸ“‚ Article πŸ“… 2010 πŸ› American Society for Bone and Mineral Research 🌐 English βš– 109 KB

## Abstract The __Lrp5__ gene is a major determinant of bone mass accrual. It has been demonstrated recently to achieve this function by hampering the synthesis of gut‐derived serotonin, which is a powerful inhibitor of bone formation. In this study we analyzed plasma serotonin levels in patients w

Levels of serotonin, sclerostin, bone tu
Levels of serotonin, sclerostin, bone turnover markers as well as bone density and microarchitecture in patients with high-bone-mass phenotype due to a mutation in Lrp5
✍ Morten Frost; Tom Andersen; Fatma Gossiel; Stinus Hansen; Jens Bollerslev; Wim v πŸ“‚ Article πŸ“… 2011 πŸ› American Society for Bone and Mineral Research 🌐 English βš– 216 KB πŸ‘ 1 views

## Abstract Patients with an activation mutation of the __Lrp5__ gene exhibit high bone mass (HBM). Limited information is available regarding compartment‐specific changes in bone. The relationship between the phenotype and serum serotonin is not well documented. To evaluate bone, serotonin, and bo