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Measurement of Plasma, Serum, and Platelet Serotonin in Individuals With High Bone Mass and Mutations in LRP5

✍ Scribed by Lee, Grace S; Simpson, Christine; Sun, Ben-Hua; Yao, Chen; Foer, Dinah; Sullivan, Becky; Matthes, Susann; Alenina, Natalia; Belsky, Joseph; Bader, Michael; Insogna, Karl L


Book ID
127250419
Publisher
American Society for Bone and Mineral Research
Year
2014
Tongue
English
Weight
474 KB
Volume
29
Category
Article
ISSN
0884-0431

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Patients with high-bone-mass phenotype o
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## Abstract The __Lrp5__ gene is a major determinant of bone mass accrual. It has been demonstrated recently to achieve this function by hampering the synthesis of gut‐derived serotonin, which is a powerful inhibitor of bone formation. In this study we analyzed plasma serotonin levels in patients w

Levels of serotonin, sclerostin, bone tu
✍ Morten Frost; Tom Andersen; Fatma Gossiel; Stinus Hansen; Jens Bollerslev; Wim v πŸ“‚ Article πŸ“… 2011 πŸ› American Society for Bone and Mineral Research 🌐 English βš– 216 KB πŸ‘ 1 views

## Abstract Patients with an activation mutation of the __Lrp5__ gene exhibit high bone mass (HBM). Limited information is available regarding compartment‐specific changes in bone. The relationship between the phenotype and serum serotonin is not well documented. To evaluate bone, serotonin, and bo