The ornithine decarboxylase (ODC) activity of Ehrlich ascites tumor cells was almost completely inhibited by treatment with either putrescine (10 mM) or 1,3diaminopropane (5 mM). 1,3-Diaminopropane treatment eradicated the cellular content of putrescine and reduced that of spermidine and spermine. P
Ornithine decarboxylase activity and the growth of neuroblastoma cells: The effects of bromoacetylcholine, bromoacetate and 1,3-diaminopropane
โ Scribed by Sharon K. Chapman; Marilyn Martin; Michael S. Hoover; Chung Y. Chiou
- Book ID
- 115774232
- Publisher
- Elsevier Science
- Year
- 1978
- Tongue
- English
- Weight
- 442 KB
- Volume
- 27
- Category
- Article
- ISSN
- 0006-2952
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## Abstract HTC cells incubated in the absence of serum for more than 14 hours have very low levels of ornithine decarboxylase, the first enzyme on the pathway of polyamine synthesis. Readdition of serum causes an increase in the activity of ODC, reaching a maximum on average 17 times above the bas
## Abstract The addition of 50 ฮผM exogenous putrescine to Swiss 3T3 cells during serum stimulation resulted in a sixfold increase in intracellular putrescine content and prevented the rise in ornithine decarboxylase activity normally seen in response to serum. SV3T3 cells had putrescine levels ten