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Organometallic Half-Sandwich Complexes Promote the Formation of Linear Oligopeptides from Amino Acid Esters

✍ Scribed by Prof. Dr. Christian Robl; Dr. Michael Maurus; Dr. Karlheinz Sünkel; Prof. Dr. Wolfgang Beck; Dr. Roland Krämer; Dr. K. Polborn

Publisher
John Wiley and Sons
Year
1996
Tongue
English
Weight
1018 KB
Volume
2
Category
Article
ISSN
0947-6539

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✦ Synopsis

Organometallic dipeptide ester complexes of the general formula [ (L)M(CI)(K'-NHZCH~CONCH,CO,R)] (1: L = Cp*, M = Rh, 2: L = Cp*, M = Ir, 3: L = q6-C6Me6, M = Ru) react smoothly with various a-L-amino acid esters in the presence of NEt, to yield the tripeptide ester complexes [(L)M(CI)(K'-

NH,CHR'CONCH,CONHCH,CO,R)]

(5-7). In the same fashion chloro K 'tetrapeptide ester complexes 10 and 11 are obtained either from tripeptide ester com-plexes or by subsequent addition of two equivalents of amino acid ester to a dipeptide ester complex. When the strong base NaOMe is used in the reaction of the diglycine ester compounds with amino LXXXVll: R. Urban.

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Catalytic Formation of Oligopeptides from α-Amino Acid Esters with (p-Cymene)ruthenium(II) Complexes
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Consecutive addition of one-equivalent portions of glycine ethyl ester to [(p-cymene)Ru(GGGOMeϪH + )Cl] leads to considerable amounts of (tetra-to nonapeptide)ruthenium complexes in a one-pot reaction, in which the (p-cymene)RuCl fragment acts as a catalyst. The analogous reaction with ala-