Organocopper reagents derived from Z-(1,3-butadienyl) magnesium chloride react regiospecifically with a,&unsaturated carbonyl compounds to give 1,4-addition products of 2-substituted-1,3-butadienes.
Organocopper conjugate addition reaction in the presence of trimethylchlorosilane
โ Scribed by A. Alexakis; J. Berlan; Y. Besace
- Book ID
- 104255711
- Publisher
- Elsevier Science
- Year
- 1986
- Tongue
- French
- Weight
- 255 KB
- Volume
- 27
- Category
- Article
- ISSN
- 0040-4039
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โฆ Synopsis
A recent communication1 on the use of the combined organocuprate-trimethylchlorosilane reagent for conjugate addition reaction to c(,b-unsaturated ketones, prompts us to report our own results concerning d,P-unsaturated ketones, esters, amides and nitriles. Organo-
๐ SIMILAR VOLUMES
A survey of conjugate additions of Yamamoto organocopper reagents to N-enoyl-4-substituted oxazolidinones is reported. Diastereofacial selectivity is reversed for 4-phenyl and 4-benzyloxazolidinones of the same relative configuration. Alkenylcopper reagents demonstrate superior results in asymmetric