Reactions of organocopper reagents derived from chloroprene. Conjugate addition and nucleophilic substitution
β Scribed by K.J. Shea; P.Q. Pham
- Publisher
- Elsevier Science
- Year
- 1983
- Tongue
- French
- Weight
- 207 KB
- Volume
- 24
- Category
- Article
- ISSN
- 0040-4039
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β¦ Synopsis
Organocopper reagents derived from Z-(1,3-butadienyl) magnesium chloride react regiospecifically with a,&unsaturated carbonyl compounds to give 1,4-addition products of 2-substituted-1,3-butadienes.
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Alkyl, aryl, and vinyl Grignard reagents were added to olefin 1I under Ni(acac) 2 or ClzNi(PPh3) 2 catalysis to give products with the general formula I in 74-95% yield. Organozincates gave similar results with Ni(acac) 2 as the catalyst.