Ni-catalyzed nucleophilic conjugate additions of Grignard and organozincate reagents to substituted 4-vinylpyridines. General synthesis of phosphodiesterase IV inhibitors

✍ Scribed by Ioannis N. Houpis; Jaemoon Lee; Ilias Dorziotis; Audrey Molina; Bob Reamer; R.P. Volante; Paul J. Reider

• Publisher: Elsevier Science
• Year: 1998
• Tongue: French
• Weight: 614 KB
• Volume: 54
• Category: Article
• ISSN: 0040-4020
• DOI: 10.1016/s0040-4020(97)10217-4

✦ Synopsis

Alkyl, aryl, and vinyl

Grignard reagents were added to olefin 1I under Ni(acac) 2 or ClzNi(PPh3) 2 catalysis to give products with the general formula I in 74-95% yield. Organozincates gave similar results with Ni(acac) 2 as the catalyst.