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Diastereoselection in the conjugate additions of organocopper reagents to N-enoyloxazolidinones

โœ Scribed by David R Williams; William S Kissel; Jie Jack Li

Publisher
Elsevier Science
Year
1998
Tongue
French
Weight
257 KB
Volume
39
Category
Article
ISSN
0040-4039

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โœฆ Synopsis

A survey of conjugate additions of Yamamoto organocopper reagents to N-enoyl-4-substituted oxazolidinones is reported. Diastereofacial selectivity is reversed for 4-phenyl and 4-benzyloxazolidinones of the same relative configuration. Alkenylcopper reagents demonstrate superior results in asymmetric additions using the 4-phenyloxazolidinone auxiliary.

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