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Functionalized isopropenyl organocopper reagents III: Conjugate additions of 3,3-diethoxyisopropenyl cuprates to enones.

โœ Scribed by J.P. Marino; J.S. Farina


Publisher
Elsevier Science
Year
1975
Tongue
French
Weight
146 KB
Volume
16
Category
Article
ISSN
0040-4039

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The new copper reagents RCu(CN)Zn I .2 BF3 1 containing various functional groups like esters, cyanides, chlorides or enoates react with p, P'-disubstituted enones to afford the Michael adducts 4-7 in high yields (81-98%). Cyano-substituted 1,4-adducts undergo a new cyclization reaction leading to t