Conjugate addition of organocopper reagents to unsaturated esters
β Scribed by Hiroshi Sakata; Isao Kuwajima
- Publisher
- Elsevier Science
- Year
- 1987
- Tongue
- French
- Weight
- 203 KB
- Volume
- 28
- Category
- Article
- ISSN
- 0040-4039
No coin nor oath required. For personal study only.
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## Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a βFull Textβ option. The original article is trackable v
Mixed cuprates ArSCu(RMgX) add rapidly to crotonates and cinnamates to give high yields of Michael adducts. Cuprates "of methyl, ethyl, isopropyl, t-butyl, phenyl and vinyl were used. Crotonates give much higher yields of adducts with cuprates using 2-methoxythiophenoxide as a ligand than with thos
N-Tosylated cx, S-unsaturated amides and lactams undergo facile conjugate addition with R'CuLi or RMgX/CuI (cat.). Stereoselective synthesis of trans-S,y-dialkyl-y-lactams
Mediated by a noncovalently bound chiral amidophosphine iigand I, reaction of organocoppers with cycloalkenones 2 aforded the corresponding J-substituted cyclo-aLk-anones 3 in 9568% ee.
Chlorotrimethylsilane, particularly if combined with hexamethylphosphoric triamide or 4\_dimethylaminopyridine, strongly promote the conjugate addition of stoichiometric organocopper reagents.