The pyrroloA C H T U N G T R E N N U N G [1,2-a]indole tricyclic ring structures are widely presented in a number of naturally occurring products and have attracted much attention due to the broad scope of their biological activities. [1] Representative examples are mitomycins, [1b] some of the most
Organocatalytic aldol reaction of indole-3-carbaldehydes with ketones: synthesis of chiral 3-substituted indoles
โ Scribed by Guo, Qi-Xiang; Wen, Wei; Fu, Li-Na; Zhang, Shun-En; Zhang, Lan-Xi; Liu, Yu-Wan; Xu, Biao; Xiong, Yan
- Book ID
- 120586522
- Publisher
- Elsevier Science
- Year
- 2013
- Tongue
- French
- Weight
- 523 KB
- Volume
- 54
- Category
- Article
- ISSN
- 0040-4039
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๐ SIMILAR VOLUMES
3-Alkylindoles were prepared in one step from indoles and ketones via a convenient reductive alkylation procedure using triethylsilane and trichloroacetic acid. Under this particular condition, unsubstituted indoles could be tolerated to afford good yields of 3-sec-alkylation products.
3-substituted indoles with benzoylperoxide led to the 3-benzoyloxy derivative.The on is discussed in terms of homolytic ipso-substitution. Recently we observed that nitronium and nitrosonium ions1 reacted with 3-substituted indoles reactito form 3-nitroindole. In this letter we report the results